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Human embryonic stem cells reveal recurrent genomic instability at 20q11.21

Nature Biotechnology [Published online: 23 November 2008 | doi:10.1038/nbt.1509] Nathalie Lefort, Maxime Feyeux, Cécile Bas, Olivier Féraud, Annelise Bennaceur-Griscelli, Gerard Tachdjian, Marc Peschanski & Anselme L Perrier
 
 
By analyzing five human embryonic stem (hES) cell lines over long-term culture, we identified a recurrent genomic instability in the human genome. An amplification of 2.5–4.6 Mb at 20q11.21, encompassing 23 genes in common, was detected in four cell lines of different origins. This amplification, which has been associated with oncogenic transformation, may provide a selective advantage to hES cells in culture.
 

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